Pigment Epithelium-Derived Factor (PEDF) Peptide Eye Drops Reduce Inflammation, Cell Death and Vascular Leakage in Diabetic Retinopathy in Ins2Akita Mice

Author:

Liu Yanling,Leo Lan Franco,McGregor Corban,Grivitishvili Anzor,Barnstable Colin J.,Tombran-Tink Joyce

Publisher

Springer Science and Business Media LLC

Subject

Genetics(clinical),Genetics,Molecular Biology,Molecular Medicine

Reference52 articles.

1. Calcutt NA, Cooper ME, Kern TS, Schmidt AM. (2009) Therapies for hyperglycaemic-induced diabetic complications: from animal models to clinical trials. Nat. Rev. 8:417–29.

2. Barber AJ, et al. (1998) Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin. J. Clin. Invest. 102:783–91.

3. Scott TM, Foote J, Peat B, Galway G. (1986) Vascular and neural changes in the rat optic nerve following induction of diabetes with streptozotocin. J. Anat. 144:145–52.

4. Barber AJ, et al. (2005) The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest. Ophthalmol. Vis. Sci. 46:2210–8.

5. Frank RN. (2004) Diabetic retinopathy. N. Engl. J. Med. 350:48–58.

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