Attenuated mTOR Signaling and Enhanced Autophagy in Adipocytes from Obese Patients with Type 2 Diabetes-Reference-Cited by-同舟云学术

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Attenuated mTOR Signaling and Enhanced Autophagy in Adipocytes from Obese Patients with Type 2 Diabetes

Published:2010-03-26 Issue:7-8 Volume:16 Page:235-246
ISSN:1076-1551
Container-title:Molecular Medicine
language:en
Short-container-title:Mol Med

Author:

Öst Anita,Svensson Kristoffer,Ruishalme Iida,Brännmark Cecilia,Franck Niclas,Krook Hans,Sandström Per,Kjolhede Preben,Strålfors Peter

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.2119/molmed.2010.00023.pdf

Reference67 articles.

1. Kim Y-B, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB. (1999) Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J. Clin. Inv. 104:733–41.

2. Goodyear L, et al. (1995) Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J. Clin. Inv. 95:2195–204.

3. Cusi K, et al. (2000) Insulin resistance differentially affects the PI 3-kinase and MAP kinasemediated signaling in human muscle. J. Clin. Inv. 105:311–20.

4. Björnholm M, Kawano Y, Lehtihet M, Zierath J. (1997) Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase acitivity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes. 46:524–7.

5. Danielsson A, Öst A, Nystrom FH, Strålfors P. (2005) Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. J. Biol. Chem. 280:34389–92.

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