Affiliation:
1. Universidade Estadual do Piauí, Brazil
2. Oncocenter, Brazil
Abstract
Fibroadenomas are the most common benign breast neoplasms. In rare cases, a carcinoma may develop within a fibroadenoma. The aim of this study was to report a case of low-grade carcinoma in situ in a fibroadenoma. A 31-year-old female, G0P0A0 and without family history of cancer, arrives at the service with an expressive breast lump growth along the year year. Core biopsy, histopathological and immunohistochemical studies showed an in-situ carcinoma in a fibroadenoma. Surgical resection was performed with a safety margin, and anatomopathological study and immunohistochemistry of the surgical specimen confirmed the core biopsy diagnosis. Currently, the patient is under annual clinical follow-up with mammography and breast ultrasound and no evidence of neoplastic disease. Although this is a rare event and few cases are described in the literature, carcinomas in situ can occur in a fibroadenoma.
Subject
General Materials Science
Reference8 articles.
1. Wu YT, Wu HK, Chen ST, Chen CJ, Chen DR, Lai HW. Fibroadenoma progress to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis? Report an unusual case. J Surg Case Rep. 2017;2017(5):rjx064. https://doi.org/10.1093/jscr/rjx064
2. Zeeshan S, Siddique S, Riaz N. Ductal carcinoma-in-situ within fibroadenoma of the breast: a case report with literature review. Int J Case Rep Images. 2018;9:100916Z01SZ2018. https://doi.org/10.5348/100916Z01SZ2018CR
3. Wu YT, Chen ST, Chen CJ, Kuo YL, Tseng LM, Chen DR, et al. Breast cancer arising within fibroadenoma: collective analysis of case reports in the literature and hints on treatment policy. World J Surg Oncol. 2014;12:335. https://doi.org/10.1186/1477-7819-12-335
4. Acrux TM. Carcinoma ductal in situ (CDIS) puro e associado ao invasivo: correlação dos achados arquiteturais, citológicos, imuno-histoquímicos e análise de recorrência [dissertation]. Salvador: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Universidade Federal da Bahia; 2017.
5. Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer Jr WD, Rados MS, et al. Long-term risk of breast cancer in women with fibroadenoma. N Engl J Med. 1994;331(1):10-5. https://doi.org/10.1056/NEJM199407073310103