CHILDREN WITH EXTREMELY LOW BODY WEIGHT: CLINICAL CHARACTERISTICS, FUNCTIONAL STATE OF THE IMMUNE SYSTEM, PATHOGENETIC MECHANISMS OF THE FORMATION OF NEONATAL PATHOLOGY

Author:

Chistyakova Guzel1,Ustyantseva Lyudmila2,Remizova Irina1,Ryumin Vladislav3,Bychkova Svetlana4

Affiliation:

1. Institution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia

2. Budgetary Institution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia

3. the Federal State Budgetary Institution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia

4. State Budgetary Institution "Ural Research Institute of Maternity and Infancy Care" of the Ministry of Health of Russia

Abstract

The purpose of the monograph, which contains a modern view of the problem of adaptation of children with extremely low body weight, is to provide a wide range of doctors with basic information about the clinical picture, functional activity of innate and adaptive immunity, prognostic criteria of postnatal pathology, based on their own research. The specific features of the immunological reactivity of premature infants of various gestational ages who have developed bronchopulmonary dysplasia (BPD) and retinopathy of newborns (RN) from the moment of birth and after reaching postconceptional age (37-40 weeks) are described separately. The mechanisms of their implementation with the participation of factors of innate and adaptive immunity are considered in detail. Methods for early prediction of BPD and RN with the determination of an integral indicator and an algorithm for the management of premature infants with a high risk of postnatal complications at the stage of early rehabilitation are proposed. The information provided makes it possible to personify the treatment, preventive and rehabilitation measures in premature babies. The monograph is intended for obstetricians-gynecologists, neonatologists, pediatricians, allergists-immunologists, doctors of other specialties, residents, students of the system of continuing medical education. This work was done with financial support from the Ministry of Education and Science, grant of the President of the Russian Federation No. MK-1140.2020.7.

Publisher

AUS PUBLISHERS

Reference26 articles.

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