Affiliation:
1. Department of Emergency Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei
2. Emergency and Trauma Center, The International Medical Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou
3. Department of Emergency Medicine, Suzhou Hospital of Anhui Medical University, Suzhou, China
Abstract
Aim
The aim of this study was to explore the relationship between peripheral circulating serum soluble suppression of tumorigenicity-2 (sST2) levels and inflammatory biomarkers in patients with acute heart failure (AHF).
Methods
One hundred and eleven consecutive AHF patients with NYHA class II-IV were enrolled, and peripheral blood was collected within 24 h of admission for the detection of NT-ProBNP, sST2, hypersensitive troponin I, cytokines, precalcitoninogen, C-reactive protein, in addition to routine standard of care blood tests.
Results
The median sST2 of 111 patients was 47.50 ng/ml (24.25–86.15 IQR), of whom 43 patients (38.7%) had sST2 35 ng/ml or less; linear correlation analysis showed that serum sST2 correlated with NT-ProBNP (r
2 = 0.32), NEU% (r
2 = 0.41), NLR (r
2 = 0.36), CRP (r
2 = 0.50), IL-18 (r
2 = 0.43) (P < 0.001), and correlated with Hs-cTnI (r
2 = 0.19), NUE (r
2 = 0.25), LYM (r
2 = -0.23), IL-2RA (r
2 = 0.29) (P < 0.05). Multiple linear regression analysis depicted that CRP (β = 0.318), IL-18 (β = 0.368), NEU% (β = 0.346), NLR (β = −0.304), and NT-ProBNP (β = 0.324) significantly correlated with sST2 values, respectively (P < 0.05). ST2 levels have a linear association with length of hospitalization.
Conclusion
Peripheral blood inflammatory markers (CRP, IL-18, NEU%, NLR) in patients with AHF had a close relationship with sST2 levels, and the mechanism of action of sST2 may be related to the inflammatory response.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,General Medicine