Role of Intracoronary Imaging in Acute Coronary Syndromes

Author:

Petrossian Gregory1ORCID,Ozdemir Denizhan2ORCID,Galougahi Keyvan Karimi3ORCID,Scheiner Jonathan4ORCID,Thomas Susan V4ORCID,Shlofmitz Richard4ORCID,Shlofmitz Evan4ORCID,Jeremias Allen5ORCID,Ali Ziad A5ORCID

Affiliation:

1. Albany Medical College, Albany Medical Center, Albany, NY

2. Division of Cardiology, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, NY

3. Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Heart Research Institute, Sydney, Australia; DeMatteis Cardiovascular Institute, St Francis Hospital – The Heart Center, Roslyn, NY

4. DeMatteis Cardiovascular Institute, St Francis Hospital – The Heart Center, Roslyn, NY

5. DeMatteis Cardiovascular Institute, St Francis Hospital – The Heart Center, Roslyn, NY; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY

Abstract

Intravascular imaging with optical coherence tomography (OCT) and intravascular ultrasound provides superior visualization of the culprit plaques for acute coronary syndromes (ACS) compared with coronary angiography. Combined with angiography, intravascular imaging can be used to instigate ‘precision therapy’ for ACS. Post-mortem histopathology identified atherothrombosis at the exposed surface of a ruptured fibrous cap as the main cause of ACS. Further histopathological studies identified intact fibrous caps and calcified nodules as other culprit lesions for ACS. These plaque types were subsequently also identified on intravascular imaging, particularly with the high-resolution OCT. The less-common non-atherothrombotic causes of ACS are coronary artery spasm, coronary artery dissection, and coronary embolism. In this review, the authors provide an overview of clinical studies using intravascular imaging with OCT in the diagnosis and management of ACS.

Publisher

Radcliffe Media Media Ltd

Subject

Cardiology and Cardiovascular Medicine

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