Baroreflex Activation Therapy for Resistant Hypertension and Heart Failure

Author:

Dyrvig Kristensen Anna Meta1,Pareek Manan2,Olsen Michael Hecht3,Bhatt Deepak L4,

Affiliation:

1. Department of Cardiology, North Zealand Hospital, Hilleroed, Denmark

2. Department of Cardiology, North Zealand Hospital, Hilleroed, Denmark; Brigham and Women’s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA

3. Cardiology Section, Department of Internal Medicine, Holbaek Hospital, Holbaek, Denmark

4. Brigham and Women’s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA

Abstract

Hypertension and heart failure are important contributors to global morbidity and mortality. Despite therapeutic lifestyle and pharmacological measures, a significant proportion of people with hypertension do not reach treatment targets. Patients with resistant or poorly controlled hypertension are at significantly increased risk of cardiovascular events, including heart failure. Since dysfunction of the sympathetic nervous system appears to play a key role in the development and progression of both hypertension and heart failure, these patients may benefit from treatment modalities aimed at reducing sympathetic function. The purpose of this paper is to provide an overview of baroreflex activation therapy as a potential treatment strategy in patients with resistant hypertension or heart failure.

Publisher

Radcliffe Group Ltd

Subject

Cardiology and Cardiovascular Medicine

Reference64 articles.

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