Prospects for personalized combination immunotherapy for solid tumors based on adoptive cell therapies and immune checkpoint blockade therapies

Author:

KATO Daiki12,YAGUCHI Tomonori1,IWATA Takashi1,MORII Kenji1,NAKAGAWA Takayuki2,NISHIMURA Ryohei2,KAWAKAMI Yutaka1

Affiliation:

1. Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine

2. Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Publisher

Japan Society for Clinical Immunology

Subject

General Medicine,Immunology,Immunology and Allergy

Reference82 articles.

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2. 2) Kawakami, Y., et al.: Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma. J Immunother. 23: 17-27, 2000.

3. 3) Tran, E., et al.: Immunogenicity of somatic mutations in human gastrointestinal cancers. Science. 350: 1387-1390, 2015.

4. 4) Galon, J., et al.: Validation of the Immunoscore (IM) as a prognostic marker in stage I/II/III colon cancer: Results of a worldwide consortium-based analysis of 1,336 patients. J Clin Oncol. 34(Suppl.): abstr 3500, 2016.

5. 5) Mokyr, M.B., et al.: Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res. 58: 5301-5304, 1998.

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