Author:
Baldwin Grace,Tracy Jack,Vingopoulos Filippos,Munsell Mary,Bennett Cade,Rodriguez Jocelyn Marie,Choi Hanna,Garg Itika,Tandias Rachel,Wescott Hannah,Finn Matthew J.,Razavi Peyman,Bannerman Augustine,Zeng Rebecca,Vavvas Demetrios G.,Husain Deeba,Kim Leo A.,Patel Nimesh A.,Miller John B.
Abstract
Background and Objective:
To evaluate the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) and visual function in healthy eyes.
Patients and Methods:
Fifty-seven eyes of 45 patients were evaluated with visual acuity (VA), contrast sensitivity (CS), and WF SS-OCTA (3 × 3, 6 × 6, and 12 × 12 mm images) on the same day. Mixed-effects multivariable regression analyses were performed.
Results:
Contrast sensitivity metrics, including CS between 6 to 18 cycles per degree (cpd) and area under the logarithm CS function, were significantly associated with vessel density (VD) and vessel skeletonized density (VSD), whereas VA was not. The largest effect size was between CS at 18 cpd and VD (β = 0.41,
P
= 0.007) and VSD (β = 0.42,
P
= 0.006) on 12 × 12 mm images.
Conclusions:
Reduced VSD and VD on WF SSOCTA was significantly associated with decreased CS, whereas VA was not. These results suggest CS could serve as a screening tool for early stage retinal and neurologic disorders.
[
Ophthalmic Surg Lasers Imaging Retina
2024;55:494–502.]