Evaluation of Oxygen Uptake Kinetic Asymmetries in Patients with Multiple Sclerosis: A Pilot Study
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Published:2018-10-31
Issue:4
Volume:6
Page:21
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ISSN:2202-946X
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Container-title:International Journal of Kinesiology and Sports Science
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language:
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Short-container-title:IJKSS
Author:
Larson Rebecca D.,Barton Monica,Farrell III John W,Cantrell Gregory S.,Lantis David J.,Black Christopher D.,Ade Carl J.
Abstract
Background of Study: Observations of limb to limb differences (bilateral asymmetry) in leg strength, power, peak oxygen uptake (VO2) and bone mineral density has been reported in individuals with Multiple Sclerosis (MS). Objetives: The purpose of this study was to quantify the magnitude of bilateral asymmetries in oxygen uptake (VO2) kinetics response to single leg cycling (SLC) in relapsing-remitting multiple sclerosis (MS) patients. Methods: Five MSpatients (2 men, 3 women; age 43±7 yrs) performed constant work rate SLC trials to determine VO2 kinetics in each leg. Asymmetry scores were used to quantify the magnitude of the bilateral asymmetries. Results: Significant asymmetries were seen in VO2 peak and parameters of VO2 kinetics. VO2peak asymmetry score was significantly different than 0% (p=0.015). Similarly,significant asymmetry for VO2 kinetic response to exercise as mean response time was observed (p=0.03). In addition the VO2 response to exercise resulted in a significant asymmetry in VO2 deficit between legs (p=0.03). No correlation between EDSS scores and any asymmetry scores existed. Conclusions: These findings provide insight into the potential differences in metabolic perturbation and limb specific symptomatic fatigue within the MS population.
Publisher
Australian International Academic Centre
Subject
Physiology (medical),Physical Therapy, Sports Therapy and Rehabilitation,Orthopedics and Sports Medicine
Cited by
1 articles.
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