Menejit Ön tanısıyla Başvuran Hastalarda Beyin Omirilik Sıvı Sonuçlarının Değerlendirilmesi

Abstract

Aim: It was aimed to determine the microorganisms and antibiotic susceptibilities obtained from cerebrospinal fluid samples (CSF). Material and Methods: CSF samples of 138 patients who admitted with a prediagnosis of meningitis to Ondokuz Mayıs University Pediatric Emergency Department between 01/01/2021-01/01/2022 was included. CSF cultures, identification of bacteria and their antibiotic susceptibilities were evaluated by VITEK 2 (bioMeriux, France) automated identification system. If the growth was detected by blood culture system, the specimen was cultivated onto the 5% blood agar, Eosin Methylene Blue agar and chocolate agar. Also, CSF samples were studied for both viral and bacterial agents with the Smart Cycler (Cepheid, USA) device working with Real-Time PCR method. In this system, Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Cytomegalovirus, Herpes simplex type-1, Herpes simplex type-2, Human herpes virus type-6 (HHV-6), Varicella zoster virus and Epstein Barr virus agents were detected. Results: Of the 138 CSF samples, 50,88% were male and 49,12% were female. The mean age of the patients was 36 ± 55 months. Bacterial agents were detected in 18 (13,8%) of the CSF samples and viral agents in 12 (9,2%) samples. Staphylococcus epidermidis (64.6%), Staphylococcus aureus (7.7%) and Streptococcus pneumonia (6.9%) took the first three places in bacterial agents. Among the viral agents, HHV-6 was the most common followed by Enteroviruses. Conclusion: It has been observed that the profiles and resistance status of microorganisms frequently seen in CSF have changed over the years.