Author:
Kit Oleg,Vodolazhskiy Dmitriy,Frantsiyants Yelena,Panina Svetlana,Rastorguev E.,Porksheyan D.
Abstract
Glioblastoma multiforme (GBM) is the most common and invasive poorly differentiated brain tumor with nearly 100 % rate of recurrence and unfavorable prognosis. The aim of the present review is to analyze recent studies and experimental results (Scopus, Web of Science, PubMed) concerning somatic mutations in glioblastoma, aberrant regulation of gene expression of signal pathways including EGFR, TGFß, etc. and markers for GBM progression. Particularly the molecular subtypes of glioblastoma and NGS results are considered in this review.
Publisher
Autonomous non-profit scientific and medical organization - Questions of Oncology
Cited by
2 articles.
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