GENETIC DAMAGES IN BLOOD CELLS UNDER COMBINED RADIATION - TOXIC ACTION. THE ROLE OF DOSE RATE

Author:

Sushko S. N.1,Malenchenko A. F.2,Ferapontova N. A.2

Affiliation:

1. Inctitute of Radiobiology of NAS of Belarus

2. Joint Institute of Energy and Nuclea Problems of NAS Belarus

Abstract

Combined influence of single or prolonged γ-irradiation 0,35 Gy (dose rate 1 Gy/h and 0,008 Gy/h) and urethan on the induction of chromosome aberrations (ChA) in bone marrow cells and micronucleus (MN) in peripheral blood polychromatic erythrocytes and also γ-irradiation, urethane, nitrogen dioxide on the induction of lung adenoma were studied. Correlation between the ratio of exchange type ChA and dose rate was of inverse direction. The lung adenoma frequency under combined action in the case of prolonged irradiation with low dose rate was increase that correlate with exchange type ChA.

Publisher

Gomel State Medical University

Subject

General Medicine

Reference10 articles.

1. Ankina M.A., Zavitaeva T.A., Semenova T.A. i dr. Issledovanie stabil'nykh aberratsii khromosom metodom g-diffeerentsial'nogo okrashchivaniya v limfotsitakh krovi cheloveka posle oblucheniya v vysokoi doze // Radiatsionnaya biologiya. Radioekologiya. - 2001. - T. 41. - № 1. - S. 43-48.

2. Bochkov N.P. Khromosomy cheloveka i obluchenie. - M.: Nauka, 1971. - 168 s.

3. Burlakova E.B., Dodina G.P., Zyuzikov N.A. i dr. Deistvie malykh doz ioniziruyushchego izlucheniya i khimicheskikh zagryaznenii na cheloveka i biotu. Programma «otsenka sochetannogo deistviya radionuklidov i khimicheskikh zagryaznenii» // Atomnaya energiya. - 1998. - T. 85. - Vyp. 6. - S. 457-462.

4. Kalistratova V.S. Metabolizm i biologicheskoe deistvie radionuklidov pri oral'nom postuplenii. - M.: Atomizdat, 1979. - S. 219-227.

5. Malenchenko A.F., Panitkov Yu.S. Biologicheskie problemy radiatsionnogo riska // Vestsi AN BSSR. Ser. fiz.- energ. navuk. - 1991. - № 3. - S. 15-26.

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