IMMUNOTOXIC AND IMMUNOREGULATORY EFFECTS OF LEAD IMPACT ON MAMMALS

Author:

Sheibak V. M.1,Pavliukovets A. Y.1

Affiliation:

1. Grodno State Medical University

Abstract

At present the study of cause-and-effect relations between the development of pathobiochemical shifts in organism and environment is one of the most topical problems of biology and medicine. Lead is one of the most common heavy metals in environment. The immune system is one of the main targets for the toxic effects of lead. Its cations modulate the functional activity of immune competent cells. Depending on the concentration and biological availability of lead, as well as on its co-factors immunostimulating or immunosupressive effects can appear. The experimental studies that have been conducted up to now make it possible to single out the impact of lead on the morphofunctional components of the immune system as one of the mechanisms of its negative effects.

Publisher

Gomel State Medical University

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