Affiliation:
1. Gomel State Medical University
Abstract
The molecular basis of hereditary pathology is now the most studied problem of medical and molecular genetics. The recent research shows that not only genetic factors may determine the development of pathological process, but also the so-called epigenetic factors including genetic and nongenetic changes in the expression of specific genes without corresponding structural changes in its nucleotide sequence. The role of the epigenetic regulation of gene activity based on abnormal methylation is assigned as one of the genetic causes of many cancers. Methylation is one of DNA modifications leading to a change in its structural and functional status, which variety of biological processes makes it subject of great interest for the study of the influence of the genome methylation on the fundamental processes in living cells.
Publisher
Gomel State Medical University
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