Intrahepatic Cholestasis of Pregnancy with Adverse Perinatal Outcomes

Abstract

Intrahepatic cholestasis of pregnanсу is the most common liver pathology in pregnant women. This disease has complex multifactorial pathogenesis, which is based on a genetic predisposition, insufficient amount of selenium in food and an incorrect reaction of a pregnant woman's body to a normal or elevated level of sex hormones and their metabolites. The main clinical manifestation is skin itching without skin rash. Intrahepatic cholestasis of pregnanсy leads to the development of pregnancy complications, such as preterm labour, often accompanied by meconium staining of amniotic fluid. In newborns, regardless of the gestational age, it contributes to the development of severe respiratory distress syndrome. These complications during pregnancy and the perinatal period are accompanied by high perinatal morbidity and mortality. This article describes three cases of pregnancy complicated by intrahepatic cholestasis, with early neonatal death of newborns. An indepth study and identification of the possible predictors of perinatal death of newborns from mothers with intrahepatic cholestasis of pregnancy will prevent negative outcomes in the future.