EFFECTS OF DRUG SUBSTANCES FRUGLYUMIN A AND FRUGLYUMIN B ON T-CELL AND B-CELL-MEDIATED IMMUNE RESPONSE IN MICE IN NORMAL AND WITH IMMUNODEFICIENCY-Reference-Cited by-同舟云学术

EFFECTS OF DRUG SUBSTANCES FRUGLYUMIN A AND FRUGLYUMIN B ON T-CELL AND B-CELL-MEDIATED IMMUNE RESPONSE IN MICE IN NORMAL AND WITH IMMUNODEFICIENCY

Published:2015-09-28 Issue:3 Volume: Page:70-74
ISSN:2708-6011
Container-title:Health and Ecology Issues
language:
Short-container-title:jour

Author:

Krivenko S. I.¹

Affiliation:

1. 9th Municipal Clinical Hospital

Abstract

The results of investigation of immunomodulatory properties of the group-specific polysaccharides A and group-specific polysaccharides B, which are the substances of drugs Fruglyumin A and Fruglyumin B, are presented. It is found that in vivo the group-specific polysaccharides provide increased immunological response of T lymphocytes to the antigen in experimental animals with normal immune status and with secondary immunodeficiency. FA and FB do not possess immunostimulating effect on B-cell immunity in experimental animals with normal immune system reactivity. In mice with secondary immunodeficiency substances of group-specific polysaccharides ensure restoration of normal value of the spleen antibody-forming cells and antierythrocyte antibody titers, indicating stimulation of antibody formation function of B-lymphocytes.

Publisher

Gomel State Medical University

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