Affiliation:
1. Republican Research Centre for Radiation Medicine and Human Ecology
Abstract
The pattern of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of resistance to clarithromycin H. pylori. During the examination of 125 patients with proved H. Pylori contamination the restriction analysis of 23S rRNA gene fragment of H. Pylori did not detect T2717C point mutation connected with the phenotype of low level of resistance to clarithromycin. The phenotype of high level of resistance to clarithromycin was detected only in 5,5 % of patients. Taking into account low indicators of phenotypic resistance, the conclusion that clarithromycin can be successfully used as a preparation of the first line of eradication therapy of H. Pylori in the Republic of Belarus has been made.
Publisher
Gomel State Medical University
Reference12 articles.
1. Helicobacter pylori - a conundrum of genetic diversity / D. G. Marshall [et al.] // Microbiology. - 1998. - Vol. 144. - P. 2925-2939.
2. Antibody response to Campylobacter pylori in an ethnic group lacking peptic ulceration / B. Dwyer [et al.] // Scand J Infect Dis. - 1988. - Vol. 20. - P. 63-68.
3. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status / D. Y. Graham [et al.] // Gastroenterology. - 1991. - Vol. 100. - P. 1495-501.
4. Grigor'ev, P. Ya. Helicobacter pylori: gastrit, duodenit (gastroduodenit), yazvennaya bolezn' i drugie gelikobakter-assotsiirovannye zabolevaniya: mater. 12-go mezhdunar. foruma po izucheniyu gastroduodenal'noi patologii i Helicobacter pylori. 2-4 sent. 1999, Khel'sinki / P. Ya. Grigor'ev, E. P. Yakovenko // Ros gastroenterol. - 1999. - № 4. - S. 38-42.
5. Rasprostranennost' khelikobakternoi infektsii u bessimptomnykh molodykh lyudei i u bol'nykh duodenal'nymi yazvami / S. I. Pimanov [i dr.] // Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. - 2004. - № 5, pril. № 23. - S. 38.