POSSIBILITIES OF FORECASTING OF CHILD IDIOPATIC THROMBOCYTOPENIC PURPURA VARIANT-Reference-Cited by-同舟云学术

POSSIBILITIES OF FORECASTING OF CHILD IDIOPATIC THROMBOCYTOPENIC PURPURA VARIANT

Published:2008-12-28 Issue:4 Volume: Page:65-69
ISSN:2708-6011
Container-title:Health and Ecology Issues
language:
Short-container-title:jour

Author:

Hoduleva S. A.¹,Romashevskaya I. P.²

Affiliation:

1. Gomel State Medical University

2. Republican Research Centre of Radiation Medicine and Human Ecology

Abstract

The clinico-immunological survey of 109 children at the age of from 2 months to 15 years suffered from idiopathic thrombocytopenic purpura (ITP) has been conducted. In the course of verification of the diagnosis, in order to evaluate trombocytopoiesis, the method of flow cytometry was used to detect the level of young forms of platelets marked with thiazole-orange. The misbalance of immune status at child ITP was detected which is characterized by T-cell link suppression (CD3+) due to T-helpers (CD4+) and T-active lymphocytes (CD3+HLA-DR+) and excessive activation of B-cell link (CD19+). Acute ITP presented in 65 % of cases, chronical one - in 35 %.Possible prognostic clinico-immunological criteria of ITP variant have been detected.

Publisher

Gomel State Medical University

Reference6 articles.

1. Khoduleva, S. A. Rasprostranennost' i struktura zabolevaemosti idiopaticheskoi trombotsitopenicheskoi purpuroi u detei Gomel'skoi oblasti Respubliki Belarus' / S. A. Khoduleva, T. I. Kozarezova // Gematologiya i transfuziologiya. - 2005. -T. 50, № 2. - S. 25-28.

2. Khoduleva, S. A. Pervichnaya autoimmunnaya trombotsitopenicheskaya purpura u detei / S. A. Khoduleva, T. I. Kozarezova. - Gomel', 2002. - 24 s.

3. Rumyantsev, A. G. Prakticheskoe rukovodstvo po detskim boleznyam / A. G. Rumyantsev, E. V. Samochatova. - M.: Medpraktika, 2002. - T. 4. - S. 373-417.

4. Gadner, H. Chronic Idiopathic thrombocytopenic purpura: incidence, treatmend and outcome / N. Gadner // Clin. Exp. Hematol. - 2001. - Vol. 53. - P. 201-221.

5. Donyush, E. K. Differentsial'naya diagnostika i sovremennaya taktika terapii idiopaticheskoi trombotsitopenicheskoi purpury u detei / E. K. Donyush, A. A. Maschan. - M., 2001. - 38 s.