THE EFFECT OF LONG-TERM INTAKE OF ATORVASTATIN AND 1-CHOLECALCIFEROL ON THE PHYSICAL AND CHEMICAL PROPERTIES OF LIPOPROTEIN BLOOD COMPLEXES OF LABORATORY RATS

Abstract

Object: to study the physical and chemical properties of the lipoprotein complexes of rats` blood in the long-term administration of statins and vitamin D. Material and methods. The experiment was performed on 4 experimental groups of rats for 90 days: 1 - intact; 2 - placebo; 3 - intragastric administration of atorvastatin; 4 - intragastric administration of atorvastatin with α-calcidol. The lipoprotein blood complexes were isolated by the method of differential ultracentrifugation. The microflow and microviscosity of the lipoprotein complexes were determined using pyrene. Results. The placebo group revealed an increase of the micropolarity of the total lipid pool of VLDL and a decrease of the microviscosity of the annulary pool of LDL and HDL. The administration of atorvastatin reduces the microviscosity of HDL. The combined application of atorvastatin and α-calcidol reduces the microviscosity of HDL. Conclusion. We have drawn a conclusion about the complex effect of stress, atorvastatin, and α-calcidol on the physical and chemical properties of the lipoprotein blood complexes and a conclusion about the positive effect of atorvastatin and α-calcidol on the microviscosity of HDL.