MODELING OF HEMORRHAGIC SHOCK

Abstract

Wiggers` method has currently become the most wide-spread method of modeling hemorrhagic shock. The proposed model is artificial to a certain degree and has its drawbacks related to the introduction of heparin, which prevents blood coagulation in small vessels and changes the vascular permeability. In a number of cases, hemorrhagic shock was reproduced by a single massive bloodletting, and the further course of the process was not controlled. The modeling of hemorrhagic shock by means of the above-mentioned method is impossible in small laboratory animals due to the small diameter of great vessels. However, the use of large laboratory animals demands high material costs. Several methods of blood sampling have been described in literature sources. However, the known methods of blood sampling cannot reproduce hemorrhagic shock in full measure. The development of a new method of modeling hemorrhagic shock in small laboratory animals is a topical area in modern experimental surgery.