Morphologic and Morphometric Parameters of the Liver Tissue of Laboratory Animals After Modeling of Chronic Stress-Reference-Cited by-同舟云学术

Morphologic and Morphometric Parameters of the Liver Tissue of Laboratory Animals After Modeling of Chronic Stress

Published:2018-12-28 Issue:4 Volume: Page:56-60
ISSN:2708-6011
Container-title:Health and Ecology Issues
language:
Short-container-title:jour

Author:

Litvinenko A. N.¹,Zinovkin D. A.¹,Ugolnik T. S.¹

Affiliation:

1. Educational institution "Gomel State Medical University"

Abstract

Objective: to study changes in the morphologic and morphometric parameters of the liver tissue in male Wistar rats under chronic Ortiz stress. Material and methods. The study was conducted on 50 male Vistor rats. The experimental group of the animals was subjected to 10-day chronic stress by Ortiz. The morphologic and morphometric parameters of the liver tissue of the animals exposed to chronic stress were studied. Results. The morphologic changes in the liver of the animals which had sustained chronic stress were characterized by impaired blood circulation and degenerative changes of hepatocytes. At the same time, a statistically significant increase in the percentage of binuclear hepatocytes (p = 0.046) and functional cariocellular index (p = 0.03) was found. Conclusion. The effect of chronic stress leads to a change in the morphologic and morphometric parameters of the liver tissue with activation of reparative processes.

Publisher

Gomel State Medical University

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