INFLUENCE OF SULFASALAZINE ON A HOMEOSTASIS OF SYSTEM OF BLOOD AT PATIENTS WITH ULCERATIVE COLITIS

Abstract

With use of a method flowing cytometry at 50 patients with ulcerative colitis influence of sulfasalazine on a homeostasis of system of blood depending on activity of N-atsetyltransferase 2 (NAT2) is studied. It is established, that in system of peripheral blood at patients with ulcerative colitis with rapid acetylator phenotype standard doses of sulfasalazine did not influence level pathological apoptosis. Thus apoptosis it was accompanied by modulation of inhibition influences of sulfasalazine on cellular proliferation by means of braking of a G1-phase of a cellular cycle. At slow acetylator phenotype standard doses of sulfasalazine initiated the tendency to interruption of pathological apoptosis. However decrease in survival rate of cells of peripheral blood owing to reception sulfasalazine at low activity of NAT2 at patients with ulcerative colitis occurred at the expense of blocking a S-phase of a cellular cycle and increase in formation of cells with micronuclei.