Affiliation:
1. Gomel State Medical University
Abstract
Cytogenetic changes in cages of peripheral blood at 62 patients with ulcerative colitis (UC) against standard treatment by sulfasalazine with use of a method of light microscopy are studied. It is established, that sulfasalazine in standard doses at patients with UC with fast type acetylation promoted accumulation neutrophils with presence of high level of segmentation, neutrophils in final phases of development and did not interrupt progressing of the basic pathogenetic link of this disease - аpoptosis. At slow acetylator with UC standard doses of sulfasalazine allowed to reduce formation neutrophils with presence of low level of segmentation, neutrophils on initial phases of development and promoted interruption pathological аpoptosis, disease causing development, i. e. UC.
Publisher
Gomel State Medical University