Clinical significance of the T(-344)C polymorphism of the aldosterone synthase gene (CYP11B2) in the prognosis of cardiorenal syndrome in diabetes mellitus-Reference-Cited by-同舟云学术

Clinical significance of the T(-344)C polymorphism of the aldosterone synthase gene (CYP11B2) in the prognosis of cardiorenal syndrome in diabetes mellitus

Published:2023-01-03 Issue:4 Volume:19 Page:48-55
ISSN:2708-6011
Container-title:Health and Ecology Issues
language:
Short-container-title:jour

Author:

Vasilkova V. N.¹^ORCID,Pchelin I. Yu.²^ORCID,Borovets Ya. A.¹^ORCID,Vasukhina I. A.³^ORCID,Mokhort T. V.⁴^ORCID

Affiliation:

1. Gomel State Medical University

2. St. Petersburg State University

3. Republican Research Center for Radiation Medicine and Human Ecology

4. Belarusian State Medical University

Abstract

Objective. To evaluate the role of the T(-344)C polymorphism of CYP11B2 gene in the development of cardiorenal syndrome (CRS) in diabetes mellitus (DM).Materials and methods. 270 patients with type 1 and type 2 diabetes aged over 25 years were examined. All patients underwent molecular genetic analysis using deoxyribonucleic acid isolated from whole venous blood.Results. The TT genotype was associated with the risk of developing CRS manifestations such as left ventricular hypertrophy (odds ratio (OR) 2.64; 95% CI (0.93–4.19), chronic heart failure (OR 4.26; 95% CI (2.26 - 8.06), subclinical atherosclerosis (OR 4.04; 95% CI (1.89 - 8.58), chronic kidney disease (CKD) (OR 10.77; 95% CI (3.56 - 32.61), and the CT genotype (OR 3.28; 95% CI (1.02 – 10.59) with CKD risk..Conclusion. There are pathogenetic associations between renin-angiotensin-aldosterone system, cardiovascular complications and a decrease of renal function. Further research is needed for a deep understanding of the complex pathogenetic mechanisms of the development and progression of cardiovascular and renal pathology.

Publisher

Gomel State Medical University

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