Genetically engineered animal models for Marfan syndrome: challenges associated with the generation of pig models for diseases caused by haploinsufficiency
Author:
Affiliation:
1. Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan
2. Laboratory of Medical Bioengineering, Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki 214-8571, Japan
Publisher
Japanese Society of Animal Reproduction
Subject
Animal Science and Zoology
Link
https://www.jstage.jst.go.jp/article/jrd/68/4/68_2022-027/_pdf
Reference43 articles.
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3. 3. Perlman RL. Mouse models of human disease: An evolutionary perspective. Evol Med Public Health 2016; 2016: 170–176.
4. 4. Perleberg C, Kind A, Schnieke A. Genetically engineered pigs as models for human disease. Dis Model Mech 2018; 11: dmm030783.
5. 5. Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 2008; 321: 1837–1841.
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