1. The pharmacology of SC- 27166: a novel on intestinal epithelial cells,31 opioid receptors of antidiarrheal agent;Dajani, E.Z.; Bianchi, R.G.; East, P.F.; Bloss, J.L.; Adelstein, G.W.; Yen, C.H.;J Pharmacol Exp Ther; 203: the delta, kappa and mu types are present in the 512-26,1977
2. Anti-diarrheal and central nervous system activities of SC-27166 (2-[3-(5-methyl1,3,4, -oxadiazol-2-yl)-3,3-diphenylpropyl]-2azabicyclo[2.2.2.]-octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brain secretion is also inhibited by morphine,5 38 and myenteric plexus. J Pharmacol Exp Ther 1977; 203: enkephalins30 and loperamide.5 81i-i3 Loperamide 527-38. increases the permeability of the serosal border of the enterocyte to chloride, which facilitates the absorption of sodium chloride and water into the submucosal space and reduces the net effect of the secretagogue on luminal fluid secretion.39 Nufenoxole might act either by inhibiting directly the action of prostaglandins, released by DSS;Mackerer, C.R.; Brougham, L.R.; East, P.F.; Bloss, J.L.; Dajani, E.Z.; Clay, G.A.
3. Inhibition by morphine of prostaglandinstimulated fluid secretion in rat jejunum;Coupar, I.M.;Br J Pharmacol,1978
4. Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists;Beubler, E.; Lembeck, F.;Naunyn-Schmiedeberg's Arch Pharmacol,1979
5. Effect of D-alanine mucosal fluid transport, or by reducing their net methionine enkephalin amide on ion transport in rabbit secretory effect by stimulating an independent absorptive process. Classically, the antidiarrhoeal activity of opioids has been attributed to their effects on motility, the slowing of intestinal transit increasing the contact time of the luminal contents with the intestinal mucosa, which promotes absorption of water and electrolytes.14 15 In a previous study in man, it was ileum;Dobbins, J.; Racusen, L.; Binder, H.J.;J Clin Invest,1980