Extending our understanding of exenatide: a rare case of angio-oedema

Author:

Mahfooz Faisal,Aylor Kourtney,Mathew, Jr. JacobORCID,Reichmuth Megan

Abstract

Exenatide is a subcutaneous injectable glucagon-like peptide 1 receptor agonist that has been approved by the Federal Drug Administration for the treatment of type 2 diabetes mellitus. While side effects such as nausea, vomiting and local hypersensitivity reactions are more commonly described, angio-oedema has never been previously reported in the literature. We present the case of a 67-year-old woman who presented to the emergency department with acute-onset tongue swelling, difficulty breathing, dizziness and diffuse itching which began shortly after receiving her first dose of intramuscular extended release (ER) exenatide. This case aims to raise awareness of the potential adverse effect of angio-oedema secondary to exenatide ER and serves as a reminder to clinicians to discuss possible adverse effects of medications and early recognition of symptoms which would prompt further medical attention.

Publisher

BMJ

Subject

General Medicine

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Angioedema secondary to exenatide;Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo;2023

2. Adverse drug reactions of GLP-1 agonists: A systematic review of case reports;Diabetes & Metabolic Syndrome: Clinical Research & Reviews;2022-03

3. Cutaneous Reactions to Antidiabetic Agents: A Narrative Review;Diabetology;2022-02-07

4. A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient;Cureus;2021-11-30

5. Exenatide/metformin;Reactions Weekly;2021-03

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