Abstract
A 41-year-old woman was referred to our hospital with a 6-week history of severe angioedema, dyspnoea and coughing. Initial investigations focused on common causes of angioedema. Clinical presentation and resistance to treatment with antihistamines and steroids made histamine-mediated angioedema unlikely. Bradykinin-mediated angioedema, such as hereditary or drug-induced angioedema, was excluded by a thorough history investigation and laboratory testing for C1-esterase and C4.In rare cases, exogen pathogens cause angioedema. After profound testing for respiratory pathogens, Bordetella pertussis toxins IgA and IgG were found to be positive, indicating recent B. pertussis infection. Pertussis toxin may be responsible for increased vascular permeability causing angioedema. With adequate antibiotic treatment, the symptoms resolved quickly.This case is an example of an atypical presentation of B. pertussis infection in an unvaccinated adult. The recent resurgence of pertussis makes early diagnosis and disease prevention by vaccination crucial.
Reference24 articles.
1. Bordetella pertussis epidemiology and evolution in the light of pertussis resurgence
2. Pertussis: new preventive strategies for an old disease;Di Mattia;Paediatr Respir Rev,2019
3. European Centre for Disease Prevention and Control . Pertussis. In: ECDC. annual epidemiological report for 2016. Stockholm, 2018.
4. European Centre for Disease Prevention and Control . Pertussis. In: ECDC. annual epidemiological report for 2017. Stockholm, 2019.
5. A report on the status of vaccination in Europe;Sheikh;Vaccine,2018
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