Abstract
A 36-year-old African American man with no medical history presented with a recent history of cough and dyspnoea. Initial chest imaging revealed diffuse bilateral lung infiltrates. A subsequent HIV test resulted positive, and he was presumptively diagnosed with AIDS, later confirmed by a CD4 of 88 cells/mm3. Empiric therapy with trimethoprim–sulfamethoxazole was initiated for presumed Pneumocystis jirovecii pneumonia. The patient’s clinical status deteriorated despite treatment. Further workup with chest CT, bronchoscopy and skin biopsy led to a diagnosis of Kaposi sarcoma with pulmonary involvement. Highly active antiretroviral therapy therapy was initiated, along with plans to start chemotherapy. However, the patient’s clinical status rapidly declined, leading to respiratory failure and eventual death. This case underlines the importance of maintaining a broad differential in immunocompromised patients presenting with respiratory symptoms.
Reference11 articles.
1. Predictive value of CD4 lymphocyte numbers for the development of opportunistic infections and malignancies in HIV-infected persons;Crowe;J Acquir Immune Defic Syndr,1991
2. Kaposi Sarcoma
3. Kaposi sarcoma pathogenesis: a triad of viral infection, oncogenesis and chronic inflammation;Douglas;Transl Biomed,2010
4. Cancer Burden in the HIV-Infected Population in the United States
5. Pulmonary Kaposi’s sarcoma as the initial presentation of human immunodeficiency virus infection;Imran;IDCases,2014