Clinical anti-inflammatory efficacy of arofylline, a new selective phosphodiesterase-4 inhibitor, in dogs with atopic dermatitis

Author:

Ferrer L.1,Alberola J.2,Queralt M.2,Brazis P.2,Rabanal R.2,Llenas J.3,Puigdemont A.2

Affiliation:

1. Department de Patologia i Producció Animals; Facultat de Veterinaria; Universitat Autònoma de Barcelona; 08193 Bellaterra Barcelona Spain

2. Departament de Farmacologia i Terapèutica; Universitat Autònoma de Barcelona; 08193 Bellaterra Barcelona Spain

3. Almirall Prodesfarma; Barcelona Spain

Publisher

Wiley

Subject

General Veterinary,General Medicine

Reference18 articles.

1. Association of the anti-inflammatory activity of phosphodiesterase-4 (PDE-4) inhibitors with either inhibition of PDE-4 catalytic activity or competition for [3H] rolipram binding;BARNETTE;Biochemical Pharmacology,1996

2. Pruritic dermatitis in asthmatic basenjigreyhound dogs: a model for human atopic dermatitis;BUTLER;Journal of the American Academy of Dermatology,1983

3. Differential inhibitor effects on cyclic AMP phosidiesterase isoforms in atopic and normal leukocytes;CHAN;Journal of Laboratory and Clinical Medicine,1993

4. In vitro pharmacology of the novel type IV phosphodiesterase (PDEIV) inhibitor, CP80,633;COHAN;Journal of Pharmacology and Experimental Medicine,1996

5. Efficacy of AHR-13268, an antiallergic compound, in the management of pruritus caused by atopic disease in dogs;DE BOER;American Journal of Veterinary Research,1992

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