1. There were no further reports to allow more detailed delineation of the condition until Der Kaloustian et al3 and Martin and Lyons Jones4 described two additional cases in 1991. Increasing awareness of this syndrome has led to a number of case reports5-8 and has opened debate on whether or not the new syndrome of multiple congenital anomaly with mental retardation and facio-cutaneousskeletal involvement described by Borochowitz et al9 in 1992 is in fact Costello syndrome.7 1012
2. A new syndrome;Costello, J.M.;NZ Med J,1971
3. A new syndrome: mental subnormality and nasal papillomata;Costello, J.M.;Aust Paediatr J,1977
4. Costello syndrome;VM, Der Kaloustian; B, Moroz; N, McIntosh; AK, Watters; S, Blaichman;Am J Med Genet,1991
5. Delineation of Costello syndrome;Martin, R.A.; Lyons Jones, K.;Am J Med Genet,1991