1. chymal damage. No other drugs had been given. There was a possible predisposition to developing hypersensitivity reactions in that retroperitoneal fibrosis might be included in the group of hypersensitivity disorders and may cause sclerosing cholangitis (Bartholomew et aL, 1963; Hellstrom and PerezStable, 1966). However, neither the liver biopsy nor the clinical course was compatible with this latter diagnosis. Five patients have been challenged with disulfiram and all developed sign of hepatic involvement again;Smith; Keeffe and,1981
2. Since the first report of disulfiram-induced liver damage in 1949, a further 20 cases have been reported. Nine patients developed hepatic coma and;Knutsen, 1949, Ranek; Andreasen, Buch,1977
3. inflammatory cells in the portal tracts has been found to be a common sign. In 3 cases focal necrosis (Ranek and Buch Andreasen;Morris;Smith; were present and in one mild cytoplasmic degeneration (Keeffe and,1977
4. Sclerosing cholangitis: its possible association with Riedel's struma and fibrous retroperitonitis. Report of two cases;BARTHOLOMEW, L.G.; CAIN, J.C.; WOOLNER, L.B.; UTZ, D.C.; FERRIS, D.O.;New England Journal of Medicine,1963
5. Disulfiram hepatotoxicity;EISEN, H.; GINSBERG, A.L.;Annals of Internal Medicine,1975