1. Amplification Fused bcr-abl loci associated with t(9; 22) translocation and Ph' chromosome: amplification Truncated amplified EGF receptor in association-with t(7; I1)
2. Future prospects It is salutory to try and envisage the extent to which DNA analysis will become an established part of clinical investigation in the future. Future applications in the diagnosis of Mendelian disease and the typing and staging of neoplasms have been discussed at length. Less obvious areas of impact include those conditions showing complex inheritance-heart disease, mental disorder, congenital abnormalities and disorders of aging, in which the increased ability to distinguish single gene effects on a multifactorial background will be exploited. Our present restricted view of the scope of mutation in disease (tables 1 and 3), determined largely by our limited ability to detect all but the Escherichia coli gene coding for xanthine-guanine phosphogrosser deletions and rearrangements, will certainly change to show enormously greater,1981
3. phase chromosomes,1975
4. Open reading frame expression vectors; a general method for antigen production in say only at a considerable cost, because as they are Escherichia coli using small;Weinstock, G.M.; Rhys, C.; Berman, M.L.;fusions to f-galactosidase. Proc currently used the techniques are undoubtedly; Nail Acad Sci USA,1983
5. Weatherall6" has argued on the basis of the 14 Carle GF, Olson MV. Separation of chromosomal DNA moleexperience with haemoglobinopathies that such meacules from yeast by orthogonal-field alternation gel electrophoresis;expensive;Nucleic Acids Res,1984