Abstract
Objectives
To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study.
Design
Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.
Setting
Children aged 0�18 years from 26 European birth cohorts.
Participants
136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood.
Main outcome measure
Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV
1
), FEV
1
/forced vital capacity) at age 6�18 years.
Results
Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3�5 years was not associated with asthma at age 6�18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results.
Conclusions
Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.
Funder
Schweizerischer Nationalfonds zur F�rderung der Wissenschaftlichen Forschung
EU FP7 Framework MedAll project
Novo Nordisk Fonden
Health Foundation
Alicia Koplowitz Foundation 2017
Generalitat Valenciana
Netherlands Asthma Foundation
Polish Ministry of Science and Higher Education
Seventh Framework Programme
FrieslandCampina
Forskningsr�det f�r Arbetsliv och Socialvetenskap
Forskningsr�det i Syd�stra Sverige
JDRF Wallenberg Foundation
Hartstichting
Barndiabetesfonden
Vetenskapsr�det
Svenska Forskningsr�det Formas
Swedish Asthma and Allergy research foundation
European Research Council
Hj�rt-Lungfonden
�stg�ta Brandstodsbolag
Region Stockholm
Erasmus Medisch Centrum
Forskningsr�det om H�lsa, Arbetsliv och V�lf�rd
ZonMw
Erasmus Universiteit Rotterdam
Ag�ncia de Gesti� d'Ajuts Universitaris i de Recerca
European Union's Horizon 2020 research and innovation programme
GlaxoSmithKline
Fundaci� la Marat� de TV3
Comissi� Interdepartamental de Recerca i Innovaci� Tecnol�gica
EU Commission
EURIP and FIRE doctoral school � Programme Bettencourt
Unidade de Investiga��o em Epidemiologia - Instituto de Sa�de P�blica da Universidade do Porto
FP7 Environment
Human Capital Operational Programme
Administra��o Regional de Sa�de Norte
Funda��o Calouste Gulbenkian
Provincial Government of Gipuzkoa
Juho Vainion S��ti�
Research Council of Finland
Department of Health of the Basque Government
Lastentautien Tutkimuss��ti�
Dunhill Medical Trust
Medical Research Council
Suomen L��ketieteen S��ti�
CIBERESP
Institut National de la Sant� et de la Recherche M�dicale
Institut F�d�ratif de Recherche and Cohort Program
Rijksinstituut voor Volksgezondheid en Milieu
National Institute for Health Research Southampton Biomedical Research Centre
EC
University of Southampton
European Regional Development Fund
Funda��o para a Ci�ncia e a Tecnologia
University Hospital Southampton National Health Service Foundation Trust
British Lung Foundation
Beca de la IV convocatoria de Ayudas a la Investigaci�n en Enfermedades Neurodegenerativas de La Caixa
Food Standards Agency
British Heart Foundation
Fondation pour la Recherche M�dicale
Institut de Veille Sanitaire
Norges Forskningsr�d
Paris-Sud University
Mead Johnson Nutrition
Federal Ministry for Environment
Leibniz Research-Institute for Environmental Medicine at the University of D�sseldorf
Fundaci�n NOE Alimerka
Netherlands Ministry of Planning, Housing and the Environment
Instituto de Salud Carlos III
Longfonds
Universidad de Oviedo
Netherlands Ministry of Health, Welfare and Sport
French Agency for Environment Security
Asthma and Lung UK
Netherlands Organization for Scientific Research
Obra Social Cajastur/Fundaci�n Liberbank
Public Health Service South Limburg
Universiteit Maastricht
French Speaking Association for the Study of Diabetes and Metabolism
French Ministry of Health Perinatal Program
Bundesministerium f�r Bildung, Wissenschaft, Forschung und Technologie
Mutuelle G�n�rale de l��ducation Nationale
National Institute for Research in Public Health
Fondation Nestl�
TU Munich
National Agency for Research
Research Institute at Marien-Hospital Wesel
Ludwig-Maximilians-Universit�t M�nchen
Institut National de Pr�vention et d'�ducation pour la Sant�
Helmholtz Zentrum Munich
Pharmacy Foundation
Danish Regional Committees
Egmont Fonden
Danmarks Grundforskningsfond
Lundbeck Foundation
March of Dimes Birth Defects Foundation
Strategiske Forskningsr�d
European Research Council Advanced Grant META-GROWTH
Ministeriet Sundhed Forebyggelse
The Capital Region Research Foundation
Irish Department of Health and Children�s Health Promotion Policy Unit
Health Research Board