Clinical features and associated factors of impaired ventilatory efficiency: findings from the ECOPD study in China

Author:

Deng ZhishanORCID,Wu FanORCID,Wan Qi,Dai CuiqiongORCID,Lu LifeiORCID,Peng Jieqi,Zhou Kunning,Wu Xiaohui,Tang Gaoying,Huang Suyin,Cai Guannan,Huang Peiyu,Wang ZihuiORCID,Zheng Youlan,Yang Huajing,Zhao Ningning,Xiao Shan,Wen XiangORCID,Sun Ruiting,Yang Changli,Huang Yongqing,Chen Rongchang,Zhou YuminORCID,Ran PixinORCID

Abstract

BackgroundImpaired ventilatory efficiency during exercise is a predictor of mortality in chronic obstructive pulmonary disease. However, little is known about the clinical features and associated factors of impaired ventilatory efficiency in China.MethodsWe conducted a cross-sectional community-based study in China and collected demographic and clinical information, cardiopulmonary exercise testing, spirometry, and CT data. Impaired ventilatory efficiency was defined by a nadir ventilatory equivalent for CO2production above the upper limit of normal. Multivariable linear and logistic regression models were used to explore the clinical features and associated factors of impaired ventilatory efficiency.ResultsThe final analyses included 941 subjects, 702 (74.6%) of whom had normal ventilatory efficiency and 239 (25.4%) had impaired ventilatory efficiency. Participants with impaired ventilatory efficiency had more chronic respiratory symptoms, poorer lung function and exercise capacity, and more severe emphysema (natural logarithm transformation of the low-attenuation area of the lung with attenuation values below −950 Hounsfield units, logLAA−950: 0.19±0.65 vs −0.28±0.63, p<0.001) and air trapping (logLAA−856: 1.03±0.65 vs 0.68±0.70, p<0.001) than those with normal ventilatory efficiency. Older age (60–69 years, OR 3.10 (95% CI 1.33 to 7.21), p=0.009 and 70–80 years, OR 6.48 (95% CI 2.56 to 16.43), p<0.001 vs 40–49 years) and smoking (former, OR 3.19 (95% CI 1.29 to 7.86), p=0.012; current, OR 4.27 (95% CI 1.78 to 10.24), p=0.001 vs never) were identified as high risk factors of impaired ventilatory efficiency.ConclusionsImpaired ventilatory efficiency was associated with poorer respiratory characteristics. Longitudinal studies are warranted to explore the progression of individuals with impaired ventilatory efficiency.

Funder

the grant of State Key Laboratory of Respiratory Disease

the Foundation of Guangzhou National Laboratory

the National Natural Science Foundation of China

the Clinical and Epidemiological Research Project of State Key Laboratory of Respiratory Disease

Publisher

BMJ

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3