Abstract
BackgroundAsthma is a common disease and a major public health concern. Respiratory symptoms are related to its prognosis, which in turn associates with lung function. Still this association on a long-term basis is not entirely understood.AimTo study the association of the type and number of respiratory symptoms with FEV1 and FEV1 decline in women and men with asthma.MethodA population-based cohort of adults with asthma was examined at study entry between 1986 and 2001 and at follow-up between 2012 and 2014, and n=977 had valid measurements of FEV1 on both occasions. Data regarding respiratory symptoms at study entry (recurrent wheeze, dyspnoea, longstanding cough and productive cough) were analysed in relation to FEV1 and annual decline in FEV1, both unadjusted and adjusted for other potentially associated factors by linear regression.ResultsFor both sexes recurrent wheeze and dyspnoea were associated with lower FEV1 at study entry and follow-up, while productive cough was associated with lower FEV1 only at follow-up. No associations were found between the type of symptoms and annual decline in FEV1. In adjusted analyses, the association between recurrent wheeze and lower FEV1 both at study entry and follow-up remained significant among women. Also, the association between a higher number of symptoms with lower FEV1 both at study entry and follow-up were present for both sexes and remained after adjustment.ConclusionsParticularly recurrent wheeze and a higher number of respiratory symptoms may predict lower lung function also in the long run among women and men with asthma.
Funder
Hjärt-Lungfonden
ALF
Norrbottens Läns Landsting
Astma- och Allergiförbundet
Swedish Research Council
Nordic council
Umeå University
Subject
Pulmonary and Respiratory Medicine
Reference40 articles.
1. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the global burden of disease study 2015;Soriano;Lancet Respir Med,2017
2. The economic consequences of asthma among adults in Sweden
3. All-cause mortality in asthma. The importance of age, comorbidity, and socioeconomic status;Putcha;Ann Am Thorac Soc,2014
4. Global Initiative for Asthma . Global strategy for asthma management and prevention, 2018. Available: www.ginasthma.org
5. POPULATION DISPARITIES IN ASTHMA
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献