1. MacSween cussed in Dr Colin Hindson and colleagues' paper (p 1368) can be most uncomfortable for patients. We have known about this now for over two years, and the company concerned have issued cards for patients warning them how to reduce its frequency. Were any of better measure of a drug's acceptability is the frequency of drug discontinuance due both to side RNM, Kissen LH, Cunningham NE;Goudie, B.M.; Birnie, G.F.; Watkinson, G.;Lancet,1982