1. The parasympathetic nervous system appears to be involved in the pathogenesis of asthma in man6 as well as experimental asthma in animal studies.2 Using ipratropium bromide, an atropine derivative given locally as an inhaled aerosol, we have demonstrated symptomatic improvement in asthmatic children during a four-week treatment period. The peak flow data are less conclusive but a significant improvement in PEFR did occur in the mornings. Changes in PEFR were small but as a group these patients achieved levels which were around 80% of predicted means, so a great deal of improvement Altounyan REC. Variation of drug action on airway obstruction in man;Thorax,1964
2. Role of the vagus in experimental asthma in dogs;Gold, W.M.; Kessler, G.F.; Yu, Y.C.;J Appl Physiol,1972
3. Effect of SCH 1000 in allergen-induced asthma;Cockcroft, D.W.; Ruffin, R.E.; Hargreave, F.E.;Clin Allergy,1978
4. SCH 1000 in psychogenic asthma;Rebuck, A.S.; Marcus, H.I.;Scand J Respir Dis,1979
5. Acute effects of ipratropium bromide (ITBR, SCH 1000, Atrovent), a review of previous studies;Simonsson, B.G.;Scand J Respir Dis,1979