Author:
Weinreb M,Day P J,Niggli F,Powell J E,Raafat F,Hesseling P B,Schneider J W,Hartley P S,Tzortzatou-Stathopoulou F,Khalek E R,Mangoud A,El-Safy U R,Madanat F,Al Sheyyab M,Mpofu C,Revesz T,Rafii R,Tiedemann K,Waters K D,Barrantes J C,Nyongo A,Riyat M S,Mann J R
Subject
Pediatrics, Perinatology, and Child Health
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1. Our aims were to assess the possible role of EBV in the aetiology of Hodgkin's disease in children from different parts of the world. We analysed 277 biopsies from 10 countries with climates ranging from temperate to tropical and with varying socioeconomic conditions. In agreement with previous studies20 21 we found young age at diagnosis and mixed cellularity subtype were more common in children from developing countries. We note that the geographical distribution of strongly EBV related Hodgkin's disease appears to be very similar to that of EBV related Burkitt's lymphoma. While we showed a strong association between mixed cellularity subtype and EBV this did not account for the differences in LMP 1 positivity between countries
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