Predictors of surgical complications in boys with hypospadias: data from an international registry
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Published:2023-10
Issue:4
Volume:6
Page:e000599
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ISSN:2516-5410
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Container-title:World Journal of Pediatric Surgery
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language:en
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Short-container-title:World Jnl Ped Surgery
Author:
Scougall Kathryn, Bryce Jillian, Baronio Federico, Boal Rachel L, Castera Jose Roberto, Castro Sebastián, Cheetham Tim, Costa Eduardo Corrêa, Darendeliler Feyza, Davies Justin H, Dirlewanger Mirjam, Gazdagh Gabriella, Globa Evgenia, Guerra-Junior Gil, Guran Tulay, Herrmann Gloria, Holterhus Paul-Martin, Akgül Ahsen Karagözlü, Markosyan Renata, McElreavey Kenneth, Miranda Marcio Lopes, Nordenstrom Anna, O’Toole Stuart, Poyrazoglu Sukran, Russo Gianni, Schwitzgebel Valerie, Stancampiano Marianna, Steigert Michael, Ahmed S Faisal, Lucas-Herald Angela KORCID
Abstract
BackgroundComplications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence.MethodsData from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher’s exact tests and spearman’s correlation tests were performed on the data to assess associations between clinical factors and complication rates.ResultsOf the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications.ConclusionsBoys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation.
Funder
Chief Scientist Office
Subject
Pediatrics, Perinatology and Child Health,Surgery
Reference19 articles.
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