1. higher than those seen in postmenopausal controls. This raises the issue of how low serum oestrogen concentrations have to be for bone loss to occur. This is difficult to assess directly, but evidence is available from studies of postmenopausal women using oestrogen replacement therapy. Treatment with transdermal oestradiol, which produces serum oestradiol concentrations around 110-160 pmol/l and a proportionate rise in oestrone concentrations, has been shown to arrest bone loss in postmenopausal women.23 29 Although a definite dose-response relation exists between oestrogen dosage and the bone response when oestrogen is given orally,30 this is difficult to translate into serum oestradiol concentrations because several biologically active metabolites;J.U.L.Y.,1991
2. Spinal mineral loss in oophorectomised women: determination by quantitative computed tomography;Cann, C.E.; Genant, H.K.; Ettinger, B.; Gordan, G.S.;JAMA,1980
3. Bone mineralization in women following successful treatment of Hodgkin's disease;Redman, JR, Bajorunas; DR, Wong; G, McDermott; K, Gneco; C, Schneider; R.;Amj Med,1988
4. Decreased spinal mineral content in amenorrheic women;Cann, C.E.; Martin, M.C.; Genant, H.K.; Jaffe, R.B.;JAMA,1984
5. Osteoporosis in women with anorexia nervosa;Rigotti, N.A.; Nussbaum, SR, Herzog D.)B.; Neer, R.M.;N Engli Med,1984