Author:
van de Sande Marleen G H,Gerlag Danielle M,Lodde Beatrijs M,van Baarsen Lisa G M,Alivernini Stefano,Codullo Veronica,Felea Ioana,Vieira-Sousa Elsa,Fearon Ursula,Reece Richard,Montecucco Carlomaurizio,Veale Douglas J,Pitzalis Costantino,Emery Paul,Klareskog Lars,McInnes Iain B,Tak Paul P
Abstract
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
Subject
General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology
Cited by
97 articles.
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