Lung cancer risk in painters: results from the SYNERGY pooled case–control study consortium
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Published:2020-10-28
Issue:4
Volume:78
Page:269-278
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ISSN:1351-0711
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Container-title:Occupational and Environmental Medicine
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language:en
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Short-container-title:Occup Environ Med
Author:
Guha NeelaORCID, Bouaoun Liacine, Kromhout HansORCID, Vermeulen Roel, Brüning Thomas, Behrens Thomas, Peters Susan, Luzon Véronique, Siemiatycki JackORCID, Xu MengtingORCID, Kendzia Benjamin, Guenel PascalORCID, Luce DanièleORCID, Karrasch Stefan, Wichmann Heinz-Erich, Consonni DarioORCID, Landi Maria Teresa, Caporaso Neil E, Gustavsson PerORCID, Plato Nils, Merletti Franco, Mirabelli Dario, Richiardi Lorenzo, Jöckel Karl-Heinz, Ahrens Wolfgang, Pohlabeln Hermann, TSE Lap Ah, Yu Ignatius Tak-Sun, Tardón Adonina, Boffetta PaoloORCID, Zaridze David, 't Mannetje Andrea, Pearce NeilORCID, Davies Michael P A, Lissowska Jolanta, Świątkowska Beata, McLaughlin John, Demers Paul A, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Pándics Tamás, Fabianova Eleonora, Mates Dana, Forastiere Francesco, Bueno-de-Mesquita Bas, Schüz Joachim, Straif KurtORCID, Olsson AnnORCID
Abstract
ObjectivesWe evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project.MethodsData were pooled from 16 participating case–control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters). Multivariable unconditional logistic regression models were adjusted for age, sex, centre, cigarette pack-years, time-since-smoking cessation and lifetime work in other jobs that entailed exposure to lung carcinogens.ResultsEver having worked as a painter was associated with an increased risk of lung cancer in men (OR 1.30; 95% CI 1.13 to 1.50). The association was strongest for construction and repair painters and the risk was elevated for all histological subtypes, although more evident for small cell and squamous cell lung cancer than for adenocarcinoma and large cell carcinoma. There was evidence of interaction on the additive scale between smoking and employment as a painter (relative excess risk due to interaction >0).ConclusionsOur results by type/industry of painter may aid future identification of causative agents or exposure scenarios to develop evidence-based practices for reducing harmful exposures in painters.
Funder
German Social Accident Insurance
Subject
Public Health, Environmental and Occupational Health
Reference38 articles.
1. IARC . Cancer today, 2020. Available: http://gco.iarc.fr/today/home [Accessed 7 Feb 2020]. 2. Peto R , Lopez AD , Boreham J , et al . Mortality from tobacco in developed countries, 1950-2000. Oxford University Press: Oxford, 1994. 3. IARC . Personal habits and indoor combustions. IARC Monogr Eval Carcinog Risks Hum 2012;100(Pt E). 4. Chemical agents and related occupations;IARC Monogr Eval Carcinog Risks Hum,2012 5. Identifying occupational carcinogens: an update from the IARC Monographs
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