1. It produces vasodilatation by antagonising the vasoconstrictor effects of adrenaline. In 1969 Jordan first demonstrated the efficacy ofphentolamine in a clinical situation.'4 This case involved a dental assistant who had deliberately injected adrenaline into her finger to stop arterial bleeding from a laceration and developed an ischaemic digit. After the administration of 5 ml of 0.1% phentolamine to the finger there was reversal of the digital ischaemia. Since then there have been several case reports documenting the efficacy of phentolamine for this purpose.',8
2. Accidental intra-arterial injection of epinephrine treated with phentolamine;Robert, JR, Kvisanda; T.J.;Ann Emerg Med,1989
3. Treatment of accidental epinephrine injection in a finger;Desmukh, N.; Tolland, J.T.;J Emerg Med,1989
4. Epinephrine-induced vasospasm reversed by phentolamine digital block;Maguire, W.M.; Reisdorff, E.G.; Smith, D.; Wiegenstein, J.G.;Am J Emerg Med,1990
5. The reversal of the ischaemic effects of epinephrine on the finger with local injections of phentolamine;Markovchick, V.; Burkhart, K.K.;J Emerg Med,1991