Abstract
ObjectiveArterial stiffness is an early and detectable marker of vascular changes leading to atherosclerotic cardiovascular disease (ACVD). Our objective was to compare the effectiveness of different types of exercise in reducing arterial stiffness in children and adolescents.DesignA systematic review and network meta-analysis (NMA) was conducted including experimental studies reporting the effects of exercise interventions on pulse wave velocity (PWV) in children and adolescents.Data sourcesCochrane Central Register of Controlled Trials, EMBASE (via Scopus), PubMed (via Medline) and Web of Science from database inception to 25 March 2022.Eligibility criteriaExperimental studies reporting the effects of exercise interventions on PWV in children and adolescents.ResultsFourteen studies were included in the NMA, all of them were randomised controlled trials except one quasi-experimental study, with an overall risk of bias of some concern. Regarding PWV reduction, all exercise modalities were more effective than control, with standardised mean difference ranging from −1.93 (95% CI: −2.84 to –1.02) and −1.11 (95% CI: −2.01 to –0.21) for aerobic exercise and high intensity interval training (HIIT), respectively, to −0.59 (95% CI: −1.39 to 0.22) for combined exercise. Only sensorimotor training was not superior to the control group 0.11 (95% CI: −1.10 to 1.32).ConclusionOur results support that exercise interventions, especially aerobic exercise or HIIT, can improve arterial stiffness at early ages. The potential to address ACVD early and mitigate long-term consequences via exercise interventions in children and adolescents with higher arterial stiffness requires further investigation.PROSPERO registration numberCRD42022322536.
Funder
Ministry of Education
ERDF
University of Castilla-La Mancha
Subject
Physical Therapy, Sports Therapy and Rehabilitation,Orthopedics and Sports Medicine,General Medicine
Reference73 articles.
1. World Health Organization . Noncommunicable diseases country profiles 2018. 2018.
2. Lauer RM , Shekelle RB . Childhood prevention of atherosclerosis and hypertension. Raven Press, 1980.
3. Berenson GS . Causation of cardiovascular risk factors in children: perspectives on cardiovascular risk in early life. Raven Press, 1986.
4. Health consequences of obesity;Berenson;Pediatr Blood Cancer,2012
5. Drozdz D , Alvarez-Pitti J , Wójcik M , et al . Obesity and cardiometabolic risk factors: from childhood to adulthood. Nutrients 2021;13:4176. doi:10.3390/nu13114176
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