Lead and zinc concentrations in plasma, erythrocytes, and urine in relation to ALA-D activity after intravenous infusion of Ca-EDTA.

Author:

Ishihara N,Shiojima S,Hasegawa K

Publisher

BMJ

Subject

Public Health, Environmental and Occupational Health

Reference18 articles.

1. Lead, air born lead in perspective;National Research Council;Washington DC: National Academy of Science,1972

2. Ca-EDTA 2Na and the erythrocytes. As whole blood is used as the enzyme source in the experiments shown in fig 2, the inhibition of the ALA-D activity by the carry-in of Ca-EDTA 2Na or plasma lead is possible. The carry-in of Ca-EDTA 2Na into the assay system is about 3-4 x 10-5M (final concentration), because the calculated maximum concentration of Ca-EDTA 2Na in the circulating blood is 0-43 mM. As shown in fig 4, the decrement of ALA-D activity is less than 20% of calcium ethylenediamine-tetra-acetate in the diagnosis of lead poisoning;Br J Ind Med,1959

3. Editorial comment in: Zielhuis RL. Interrelationship of biological responses to the absorption of inorganic lead;Kehoe, R.A.;Arch Environ Health,1971

4. Attempt on the determination of biologically active lead in organism in experimental poisoning;Teisinger, J.; Ptevovska, F.; Sedivec, V.; Flek, J.; Roth, Z.;Internationale Archiv fiir Gewerbepathologie und Bewerbenhygiene,1969

5. Biochemical responses to provocative chelation by edeate disodium calcium;Teisinger, J.;Arch Environ Health,1971

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