Long term risk of death and readmission after hospital admission with covid-19 among older adults: retrospective cohort study

Abstract

AbstractObjectivesTo characterize the long term risk of death and hospital readmission after an index admission with covid-19 among Medicare fee-for-service beneficiaries, and to compare these outcomes with historical control patients admitted to hospital with influenza.DesignRetrospective cohort study.SettingUnited States.Participants883 394 Medicare fee-for-service beneficiaries age ≥65 years discharged alive after an index hospital admission with covid-19 between 1 March 2020 and 31 August 2022, compared with 56 409 historical controls discharged alive after a hospital admission with influenza between 1 March 2018 and 31 August 2019. Weighting methods were used to account for differences in observed characteristics.Main outcome measuresAll cause death within 180 days of discharge. Secondary outcomes included first all cause readmission and a composite of death or readmission within 180 days.ResultsThe covid-19 cohort compared with the influenza cohort was younger (77.9v78.9 years, standardized mean difference −0.12) and had a lower proportion of women (51.7%v57.3%, −0.11). Both groups had a similar proportion of black beneficiaries (10.3%v8.1%, 0.07) and beneficiaries with dual Medicaid-Medicare eligibility status (20.1%v19.2%; 0.02). The covid-19 cohort had a lower comorbidity burden, including atrial fibrillation (24.3%v29.5%, −0.12), heart failure (43.4%v49.9%, −0.13), and chronic obstructive pulmonary disease (39.2%v52.9%, −0.27). After weighting, the covid-19 cohort had a higher risk (ie, cumulative incidence) of all cause death at 30 days (10.9%v3.9%; standardized risk difference 7.0%, 95% confidence interval 6.8% to 7.2%), 90 days (15.5%v7.1%; 8.4%, 8.2% to 8.7%), and 180 days (19.1%v10.5%; 8.6%, 8.3% to 8.9%) compared with the influenza cohort. The covid-19 cohort also experienced a higher risk of hospital readmission at 30 days (16.0%v11.2%; 4.9%, 4.6% to 5.1%) and 90 days (24.1%v21.3%; 2.8%, 2.5% to 3.2%) but a similar risk at 180 days (30.6%v30.6%;–0.1%, −0.5% to 0.3%). Over the study period, the 30 day risk of death for patients discharged after a covid-19 admission decreased from 17.9% to 7.2%.ConclusionsMedicare beneficiaries who were discharged alive after a covid-19 hospital admission had a higher post-discharge risk of death compared with historical influenza controls; this difference, however, was concentrated in the early post-discharge period. The risk of death for patients discharged after a covid-19 related hospital admission substantially declined over the course of the pandemic.