Germline testing for breast cancer patients in England: illogical to prioritise grade 1 breast cancer aged 30–39 over grade 3 aged 40–49 years?

Author:

Evans D GarethORCID,Howell Sacha J,Burghel George JORCID,Forde ClaireORCID,Lalloo Fiona,Smith Miriam JORCID,Howell Anthony,Gandhi AshuORCID,Woodward Emma Roisin

Funder

Manchester Biomedical Research Centre

Publisher

BMJ

Reference10 articles.

1. McIntosh A , Shaw C , Evans G , et al . Clinical guidelines and evidence review for the classification and care of women at risk of familial breast cancer. London: National Collaborating Centre for Primary Care/University of Sheffield.; 2017. Available: http://www.nice.org.uk [Accessed 17 Jun 2018].

2. NHS england . Available: https://www.england.nhs.uk/wp-content/uploads/2018/08/rare-and-inherited-disease-eligibility-criteria-v4.pdf

3. Clinical practice guidelines for BRCA1 and BRCA2 genetic testing

4. Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

5. Population-based germline testing of BRCA1, BRCA2, and PALB2 in breast cancer patients in the united kingdom: evidence to support extended testing, and definition of groups who may not require testing;Evans;Genet Med Open,2024

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