1. 1961; Sauti and Pietri-Tonelli, 1959b; Fontanelli and Lanforti, 1959; American Cyanamid;el al, West;Co; Chilwell and Beecham,1957
2. The product (dimethyl S-(N-methylcarbamoylmethyl) phosphorothiolate), which we shall call the thiolate analogue, is a toxic metabolite (see below) and has been isolated (Santi and;Dauterman et al.;Pietri-Tonelli; also showed that oxidation occurs slowly in air, and Santi and Pietri-Tonelli (1959 a, b) that the oxidation is accelerated by some metallic ions. The 0-methyl groups of dimethoate may undergo exchange reactions with alcohols, giving rise to changes in toxicological properties: potentiation tests, as listed later, were either commercial formulations or technical grades,1960
3. Oral dosing was by stomach tube, under ether anaesthesia except in birds and the rabbit. Dermal toxicity was examined by the method described by Edson and Noakes (1960). In acute tests animals were normally observed for seven days. LD50 values were computed by the method of Weil;Administration,1952
4. Such reactions have been observed in 2-methoxyand 2-ethoxy-ethanol (Casida and Sanderson, 1961, 1963) and in isopropanol. Any changes in other solvents are slow and are probably due to contact with moist air (see later)
5. Analytical methods have been devised for dimethoate in technical and formulated material,1963